PTSD Treatment Research Study
Researchers at the University of Pennsylvania want to learn more about how a new treatment benefits women experiencing symptoms of PTSD. Join our compensated study today!
Research Conducted in Philadelphia, PA
Compensation Provided
PTSD Symptoms
18 - 45 Years Old
Fast Facts
About Our Research Study
Help researchers at the University of Pennsylvania determine if taking estradiol (a form of estrogen) together with Prolonged Exposure (PE) therapy benefits women experiencing symptoms of PTSD.
PE is a first-line, evidence-based talk therapy that focuses on helping individuals with PTSD process memories of trauma. Previous findings have shown that the hormone estrogen facilitates people learning not to fear things they had feared before. This study will evaluate whether supplementing PE therapy with estradiol pills improves fear extinction outcomes in women with PTSD.

Study participants will receive PE therapy at no cost and may see a reduction in their symptoms.

Join our compensated study and help find better treatments for PTSD today!
Additional Information
Why is this study being done?
The purpose of this research study is to determine if taking a pill of estradiol (a form of estrogen) together with prolonged exposure (PE) therapy improves treatment outcomes in women with post-traumatic stress disorder (PTSD).
Is this study for me?
You may qualify for this study if you meet the following criteria.

Key Criteria:
  • Female
  • 18 - 45 years old
  • Experiencing symptoms of PTSD
  • On birth control (oral contraceptives, vaginal ring, or transdermal patch)
What will happen if I participate in the study?
Once enrolled, this study involves:

  • In-person study visits
  • Prolonged exposure (PE) therapy treatment sessions
  • Randomization to study drug (estradiol) or placebo
  • Memory tasks
  • Two fMRI scans
  • Blood draws
Will I be paid for being in this research study?
Compensation up to $480 is provided for your time
Will it cost me anything to participate in this study?
There is no cost for you to participate in our research study.