Finding the right fit: The SMART Trial for better depression treatment
McLean Hospital is looking for adults with depression to take part in a first-of-its-kind study to advance personalized treatment. Instead of trial and error to treat depression, researchers may be able to predict which antidepressant will work using your biological and behavioral data. Help advance depression research and sign up today!
Conducted in Massachusetts
18-64 Years Old
Fast Facts
Currently Experiencing Symptoms of Depression
Study Background
Finding the right depression treatment isn't always easy. For about half of people with depression, the first medication they try isn't the right fit.
Researchers believe that one of the reasons why matching a person to the right treatment is so difficult is because everyone has different biological indicators (biomarkers) that may contribute to their depression in unique ways.
The purpose of this study is to learn more about specific biomarkers associated with anhedonia (loss of interest) in people with depression and evaluate how they may help predict antidepressant efficacy.
Your participation in this study could lead to better treatments for depression in the future. Further research and join our compensated study today!
Researchers believe that one of the reasons why matching a person to the right treatment is so difficult is because everyone has different biological indicators (biomarkers) that may contribute to their depression in unique ways.
The purpose of this study is to learn more about specific biomarkers associated with anhedonia (loss of interest) in people with depression and evaluate how they may help predict antidepressant efficacy.
Your participation in this study could lead to better treatments for depression in the future. Further research and join our compensated study today!
Study Background Finding the right depression treatment isn't always easy. For about half of people with depression, the first medication they try isn't the right fit. Researchers believe that one of the reasons why matching a person to the right treatment is so difficult is because everyone has different biological indicators (biomarkers) that may contribute to their depression in unique ways. The purpose of this study is to learn more about specific biomarkers associated with anhedonia (loss of interest) in people with depression and evaluate how they may help predict antidepressant efficacy. Your participation in this study could lead to better treatments for depression in the future. Further research and join our compensated study today! |
Additional Information
The purpose of this study is to learn more about depression biomarkers and how they may help predict a person's response to antidepressant treatment.
You may qualify for this study if you meet the following criteria.
Inclusion Criteria:
Inclusion Criteria:
- 18-64 years old
- Diagnosed with depression
- Not on antidepressant medications, or taking antidepressants that aren't working
- No unstable medical conditions
- No cocaine, stimulant, or opioid disorder
- Able to travel to Belmont, MA (Travel reimbursements available)
The entire study involves 9 sessions (3 in-person and 6 remote) over about 10 weeks. Visits include:
The initial session (in-person) is a screening session that includes EKG, questionnaires, drug and pregnancy tests, and a clinical interview.
The second session (in-person) is a scanning session. This can include an MRI, EEG, questionnaires, drug tests, behavioral tasks, and an activity watch.
In sessions 3-8 (remote) medication will be dispensed along with having check-ins with a doctor.
The last session (in-person) is the last scanning session. This can include an MRI, EEG, questionnaires, drug tests, behavioral tasks, and an activity watch.
Most appointments will be scheduled during normal working hours.
The initial session (in-person) is a screening session that includes EKG, questionnaires, drug and pregnancy tests, and a clinical interview.
The second session (in-person) is a scanning session. This can include an MRI, EEG, questionnaires, drug tests, behavioral tasks, and an activity watch.
In sessions 3-8 (remote) medication will be dispensed along with having check-ins with a doctor.
The last session (in-person) is the last scanning session. This can include an MRI, EEG, questionnaires, drug tests, behavioral tasks, and an activity watch.
Most appointments will be scheduled during normal working hours.
Participants will be compensated up to $710 for their participation.
There is no cost for you to participate in the study.